Mannose
Simple sugar, humectant. Pulls water into the stratum corneum; in prebiotic formulas claimed to support the skin microbiome.
Evidence by route
Topical application
Humectant effect is expected for simple sugars. Evidence for topical microbiome effects is limited to marketing-driven studies.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Mannose (D-Mannose) is a simple sugar (monosaccharide), an epimer of glucose. In skin it is part of glycoproteins and proteoglycans of the extracellular matrix. In cosmetics – humectant and prebiotic. Mechanism. Binds water in the stratum corneum. Supports glycoprotein synthesis in the dermis. As a prebiotic it feeds normal skin microbiota and supports microbiome balance. Where applied. Serums and creams for sensitive skin and microbiome dysbiosis, anti-couperose products, post-procedure creams. Concentration 0.5–3%. A rare ingredient in niche and pharmacy cosmetics. Evidence base. Few topical clinical RCTs. The main evidence base for mannose is oral use in urinary tract infections (Cochrane 2022, moderate-quality evidence). Skin evidence is still insufficient. Pregnancy and lactation – topically safe. Hypoallergenic, non-comedogenic.
Frequently asked questions
Is Mannose safe during pregnancy?
Mannose is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Mannose for?
Mannose suits: normal, dry, oily, combination, sensitive.
What is Mannose and what does it do in cosmetics?
Simple sugar, humectant.
What's the INCI name for Mannose?
The INCI name is Mannose. It may also appear as: D-Mannose.
See Mannose in a product composition right on the store page
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Marula Oil, Methionine, Methyl Gluceth-20, Methylsilanol Mannuronate, Rice Amino Acids, Anhydroxylitol, Decanediol, Hydrogenated Coconut Acid
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