Essential sulphur-containing amino acid. In cosmetics appears in amino acid complexes and in formulas claiming to strengthen the hair follicle: methionine is a sulphur source for keratin synthesis. On skin works as an NMF component with antioxidant potential due to its sulphur group.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Safe amino acid component. Hair-strengthening claims are better supported systemically than topically.
Methionine (L-Methionine) is an essential sulfur-containing alpha-amino acid. In skin it serves as a methyl donor in methylation reactions and a precursor of cysteine and glutathione – key antioxidant molecules. Mechanism. Supports glutathione synthesis – the main keratinocyte antioxidant. The sulfur group protects proteins from oxidative stress. Humectant: binds water in the stratum corneum. Where applied. Serums and creams for mature skin and pigmentation, damaged-hair products (methionine is a structural component of keratin). Concentration 0.1–2%. Often in amino-acid complexes with lysine, arginine, cysteine. Evidence base. No clinical RCTs of topical methionine. Main base – oral use in liver and hair disorders. CIR confirmed safety. Pregnancy and lactation – topically safe. Hypoallergenic, non-comedogenic.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
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Methionine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Methionine suits: normal, dry, combination, oily, sensitive.
Essential sulphur-containing amino acid.
The INCI name is Methionine. It may also appear as: L-Methionine, Метионин.
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