Polymer of glutamic acid from Bacillus subtilis fermentation. Humectant with high water-holding capacity, several times that of hyaluronic acid in vitro.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Modern humectant with pilot clinical data on hydration.
Polyglutamic Acid (γ-PGA, PGA) is a polymer of glutamic acid, produced by Bacillus subtilis (natto) fermentation. Gives the same skin feel as hyaluronic acid with higher in vitro water-holding capacity – retains 5-10 times its weight in water (Lin 2002). Where applied. Serums, creams, masks (0.1-2%). More popular than hyaluronic acid in Japanese and Korean cosmetics – cheaper to produce, more stable. In Spain – Filorga, Sesderma, Indeed Labs Hydraluron+ (with PGA). Mechanism. Humectant: forms a thin hydrating film on the skin surface, retains moisture. Also stimulates the skin's own hyaluronic acid production in fibroblasts (Yokoi 2003). Evidence base. Ben-Zur (J Cosmet Sci 2008) and Yokoi (J Med Invest 2003) showed 30-45% moisturisation gains over 4 weeks at 0.5%. Effect comparable to hyaluronic acid. Less tacky in formula. Safety. CIR has not assessed separately, but the component is on the FDA GRAS list (as a food additive). Hypoallergenic, non-comedogenic. Pregnancy and lactation – safe. Suitable in any product.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Polyglutamic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Polyglutamic Acid suits: normal, dry, oily, combination, sensitive.
Polymer of glutamic acid from Bacillus subtilis fermentation.
The INCI name is Polyglutamic Acid. It may also appear as: PGA, полиглутаминовая кислота.
Published: · updated: