The active form of vitamin B1. It joins a cofactor complex to support skin. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Vitamin B1, a cofactor. Safe.
Thiamine Diphosphate is the coenzyme form of vitamin B1. INCI: Thiamine Diphosphate. In cells it takes part in energy metabolism; in cosmetics it is marketed as a component for skin vitality. The role of vitamin B1 matters when taken orally, but cosmetics act topically, which is a different context. Topical clinical data that applying thiamine diphosphate gives a measurable skincare effect are limited, so it is a supporting component rather than a lead active with a proven result. Pregnancy safety. Topical use, low systemic absorption, no evidence of harm. It can be used during pregnancy and lactation. Tolerance. Irritation and allergen potential are low.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Thiamine Diphosphate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Thiamine Diphosphate suits: normal, dry, combination, oily, sensitive.
The active form of vitamin B1.
The INCI name is Thiamine Diphosphate. It may also appear as: Тиамина дифосфат, Витамин B1, Cocarboxylase.
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