Trehalose
Disaccharide of two glucose molecules, synthesized by microorganisms and plants under stress. Protects cell membranes from dehydration and holds water in skin.
Evidence by route
Topical application
Mild humectant with anti-stress effect on skin. Clinical effects are limited to hydration, claimed anti-aging results have weak evidence.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Trehalose is a disaccharide of two α-glucose molecules joined by an α-1,1 bond. Synthesised by bacteria, fungi, insects and yeast under extreme stress (drought, frost, osmotic shock). Not produced in humans and mammals. Mechanism. Protects cell membranes from dehydration by hydrogen bonding with phospholipids – 'glass-like protection' during water loss. On skin it acts as a humectant (retains moisture) and an osmoprotector – gently shields cells from dehydration. Where applied. Post-procedure serums and creams, sensitive-skin products, reactive skin, anti-sting formulas, winter-care products. In Spain – Sesderma Hidraderm Tre, Mesoestetic Hydra-Vital, Endocare Hydractive. Evidence base. Wang 2017 RCT showed a 30-40% hydration gain over 4 weeks of 5% trehalose, comparable to glycerin. Additional effect – protection from UV-induced keratinocyte apoptosis in vitro (Norcia 2009). Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Safe as a food ingredient (E1450). Pregnancy and lactation – safe. Applicable at any stage and on any area. Particularly suited for. Dry, sensitive, reactive skin, post-procedure care (laser, peels, bio-revitalisation), rosacea patients.
Frequently asked questions
Is Trehalose safe during pregnancy?
Trehalose is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Trehalose for?
Trehalose suits: normal, dry, oily, combination, sensitive.
What is Trehalose and what does it do in cosmetics?
Disaccharide of two glucose molecules, synthesized by microorganisms and plants under stress.
What's the INCI name for Trehalose?
The INCI name is Trehalose.
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