Disaccharide of two glucose molecules, synthesized by microorganisms and plants under stress. Protects cell membranes from dehydration and holds water in skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Mild humectant with anti-stress effect on skin. Clinical effects are limited to hydration, claimed anti-aging results have weak evidence.
Trehalose is a disaccharide of two α-glucose molecules joined by an α-1,1 bond. Synthesised by bacteria, fungi, insects and yeast under extreme stress (drought, frost, osmotic shock). Not produced in humans and mammals. Mechanism. Protects cell membranes from dehydration by hydrogen bonding with phospholipids – 'glass-like protection' during water loss. On skin it acts as a humectant (retains moisture) and an osmoprotector – gently shields cells from dehydration. Where applied. Post-procedure serums and creams, sensitive-skin products, reactive skin, anti-sting formulas, winter-care products. In Spain – Sesderma Hidraderm Tre, Mesoestetic Hydra-Vital, Endocare Hydractive. Evidence base. Wang 2017 RCT showed a 30-40% hydration gain over 4 weeks of 5% trehalose, comparable to glycerin. Additional effect – protection from UV-induced keratinocyte apoptosis in vitro (Norcia 2009). Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Safe as a food ingredient (E1450). Pregnancy and lactation – safe. Applicable at any stage and on any area. Particularly suited for. Dry, sensitive, reactive skin, post-procedure care (laser, peels, bio-revitalisation), rosacea patients.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Trehalose is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Trehalose suits: normal, dry, oily, combination, sensitive.
Disaccharide of two glucose molecules, synthesized by microorganisms and plants under stress.
The INCI name is Trehalose. It may also appear as: Трегалоза.
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