Ester of xylitol and glucose. Humectant, component of Aquaxyl complex with confirmed hydration effect.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Safe humectant with accumulated evidence.
Xylitylglucoside is an ester of xylitol and glucose. A component of the Aquaxyl complex from Seppic (France) – one of the best-known cosmetic moisture-binding complexes. In Aquaxyl it combines with anhydroxylitol and xylitol for synergy. Mechanism. Humectant with extended hydration effect: beyond the classic moisture pull into the stratum corneum, it activates aquaporin-3 (AQP3) synthesis – water channels in keratinocyte membranes. Stimulates epidermal hyaluronic acid synthesis in vitro. Where applied. Moisturising serums and creams. In Spain – in Sesderma Hidraderm Hyal, Mesoestetic Hydra-Vital Factor K, ISDIN Hyaluronic Moisture lines. Aquaxyl complex in finished formulas – usually 3%, isolated xylitylglucoside – 0.5-2%. Evidence base. Seppic internal studies in 24 women over 28 days of 3% Aquaxyl use showed 25-30% hydration improvement and 15% TEWL reduction. Direct RCT comparisons with glycerin or hyaluronic acid have not been done. Safety. CIR has not evaluated it separately, but as a mixture of sugar esters it is safe. Non-sensitising, non-comedogenic. Pregnancy and lactation – safe. Usable without restrictions. Suited for. Dry, dehydrated skin, barrier recovery, anti-ageing prevention.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Xylitylglucoside is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Xylitylglucoside suits: normal, dry, oily, combination, sensitive.
Ester of xylitol and glucose.
The INCI name is Xylitylglucoside.
Published: · updated: