ModerateAntiplatelet agents (low dose) / NSAIDs (analgesic dose)×ACE inhibitor
Updated · Methodology
Mechanism
At analgesic doses (above 1 g/day), aspirin suppresses vasodilator prostaglandins and weakens the ACE-I's hypotensive effect. At cardioprotective doses (75–100 mg), the effect is minimal.
Symptoms
Gradual blood pressure rise at high aspirin doses. At cardioprotective doses, no significant changes.
Management
Cardioprotective aspirin doses (75–100 mg) are acceptable without adjustment. At high doses, monitor blood pressure and increase captopril if needed. Alternative analgesic: paracetamol.
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Sources
- ESH: 2023 ESH Guidelines for the management of arterial hypertension (2023)
- AEMPS: Ficha técnica Captopril Cinfa 50 mg comprimidos EFG (2026)– AEMPS, CIMA, nº registro 62305, revisión 03/2026, secciones 4.4 y 4.5