ModerateAntiplatelet agents (low dose) / NSAIDs (analgesic dose)×Non-dihydropyridine calcium channel blocker
Updated · Methodology
Mechanism
At high doses, aspirin weakens verapamil's antihypertensive effect via vasodilator prostaglandin suppression. At cardioprotective doses, there is no clinically significant effect.
Symptoms
Gradual blood pressure rise at high aspirin doses. At cardioprotective doses, no significant changes.
Management
Cardioprotective aspirin doses (75–100 mg) are acceptable without adjustment. At high doses, monitor blood pressure and increase verapamil if needed. Alternative analgesic: paracetamol.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- ESH: 2023 ESH Guidelines for the management of arterial hypertension (2023)
- AEMPS: Ficha técnica: Verapamilo, Manidon Retard 120 mg (nº registro 53434), sección 4.5 (2024)– AEMPS, CIMA, nº registro 53434, revisión 06/2024, sección 4.5