ModerateAntiplatelet agents (low dose) / NSAIDs (analgesic dose)×Calcium channel blocker, non-DHP (benzothiazepine derivative)
Updated · Methodology
Mechanism
Diltiazem impairs platelet function via calcium channel blockade; aspirin is an antiplatelet. Mild additive bleeding risk, rarely clinically significant.
Symptoms
Usually asymptomatic. In patients with bleeding risk factors (peptic ulcer, older age): rare gum bleeding and epistaxis.
Management
Standard combination in ischaemic heart disease. Cardioprotective aspirin doses (75–100 mg) are acceptable without special measures. In patients with bleeding risk factors: PPI cover with pantoprazole.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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Sources
- FDA: Cardizem section 7 (2014)– ; DailyMed setid f3e7ecef-f360-4987-a4f5-933214130ab2