Major
Acetylsalicylic acid × naproxen
Antiplatelet agents (low dose) / NSAIDs (analgesic dose)×NSAID, propionic acid derivative
Mechanism
Naproxen competes with aspirin for platelet COX-1 similar to ibuprofen.
Symptoms
Loss of antiplatelet effect.
Management
Separate dosing or paracetamol alternative.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.