ModerateCalcium channel blockers (dihydropyridines)×NSAID, propionic acid derivative
Updated · Methodology
Mechanism
NSAIDs weaken amlodipine's antihypertensive effect via renal prostaglandin suppression.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting naproxen. In chronic kidney disease: fluid retention and oedema risk.
Management
For short naproxen courses (5–7 days), monitor blood pressure. For chronic analgesia: switch to paracetamol or celecoxib (with PPI cover).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Naproxen tablet (Glenmark Pharmaceuticals Inc., USA) – Prescribing Information (2016)– ; DailyMed setid 6c5bb008-e66f-4ef0-bf84-aca7eb5983e9