Minor
Acetylsalicylic acid × Calcium carbonate
Antiplatelet agents (low dose) / NSAIDs (analgesic dose)×Mineral supplements. Calcium
Mechanism
Antacids accelerate renal aspirin elimination via urinary alkalinisation. At cardioprotective doses (75–100 mg/day), the effect is clinically minimal.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
At cardioprotective aspirin doses, no adjustment needed. At high anti-inflammatory doses (over 3 g/day) with simultaneous antacid for several days, efficacy may slightly drop — separate dosing by 2 hours.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.