Minor
Calcium carbonate × Colecalciferol
Mineral supplements. Calcium×Vitamins. Regulator of calcium-phosphorus metabolism
Mechanism
Vitamin D increases intestinal calcium absorption by activating calbindin in enterocytes. The synergistic effect benefits osteoporosis and calcium deficiency.
Symptoms
On a balanced dose, no symptoms. At excessive doses of vitamin D (over 4000 IU/day chronically) and calcium (over 1500 mg/day), hypercalcaemia risk: thirst, polyuria, nausea, weakness, arrhythmia.
Management
Standard combination in osteoporosis prevention and treatment: colecalciferol 800–2000 IU/day plus calcium 1000–1200 mg/day (counting dietary calcium). Check calcium and creatinine every 6 months in patients with chronic kidney disease or prior nephrolithiasis.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.