MinorMineral supplements. Calcium×Biguanides. Oral antihyperglycemic agents
Updated · Methodology
Mechanism
Calcium carbonate slightly reduces metformin intestinal absorption when taken together. Clinically significant hyperglycaemia has not been described.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
Take metformin with or just after meals; take calcium carbonate 2 hours after meals or in the evening. On the combination, monitor HbA1c on the usual schedule. In diabetics with osteoporosis, the combination is standard.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Metformin hydrochloride tablet (Sciegen Pharmaceuticals Inc) – Prescribing Information (2017)– ; DailyMed setid 4e4c4ba9-65c6-4273-8f6b-2423ab521dad