Minor
Metformin × Simeticone
Biguanides. Oral antihyperglycemic agents×Drugs for functional bowel disorders. Antifoaming agents
Mechanism
Simethicone is a surface-active silicone agent that is not absorbed in the gastrointestinal tract. No direct pharmacokinetic interaction with metformin.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. In diabetics with bloating (a metformin side effect), simethicone helps symptomatically. The combination is standard.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.