ModerateAntiplatelet agents (low dose) / NSAIDs (analgesic dose)×Angiotensin II receptor blockers (ARBs)
Updated · Methodology
Mechanism
Analgesic aspirin doses weaken the ARB's antihypertensive effect via vasodilator prostaglandin suppression. Cardioprotective doses are clinically minor.
Symptoms
Gradual blood pressure rise at high aspirin doses. At cardioprotective doses, no significant changes.
Management
Cardioprotective aspirin doses (75–100 mg) are acceptable without adjustment. At high doses, monitor blood pressure and increase valsartan if needed. Alternative analgesic: paracetamol.
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Sources
- ESH: 2023 ESH Guidelines for the management of arterial hypertension (2023)
- AEMPS: Ficha técnica: Valsartán (nº registro 70323), sección 4.5 (2025)– AEMPS, CIMA, nº registro 70323, revisión 03/2025, sección 4.5