Moderate
Alprazolam × Haloperidol
Benzodiazepines. Short-to-medium-acting anxiolytics×First-generation antipsychotics. Butyrophenone derivatives
Mechanism
Additive CNS depression and sedation. In older patients: high delirium and fall risk.
Symptoms
Deep sedation, drowsiness, ataxia, confusion (especially in older patients). Orthostatic hypotension possible (haloperidol blocks α1-adrenoceptors).
Management
The combination is used briefly in acute agitation or psychotic episodes. In older patients: lorazepam at minimum dose with olanzapine or aripiprazole (less α1-blockade than haloperidol) is preferable.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.