Critical
Amiodarone × Haloperidol
Class III antiarrhythmics (Vaughan Williams)×First-generation antipsychotics. Butyrophenone derivatives
Mechanism
Dual QT prolongation. Torsades de pointes cases reported.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.