ModerateCalcium channel blockers (dihydropyridines)×Natural opium alkaloids
Updated · Methodology
Mechanism
Additive hypotension and sedation. Morphine reduces sympathetic tone; amlodipine dilates vessels. Older patients: fall risk.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk.
Management
The combination is acceptable in palliative care and acute coronary syndrome. Titrate morphine from a low dose; monitor pulse, blood pressure, and saturation. Older patients: enhanced fall monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Verapamil hydrochloride tablet (Zydus Lifesciences Limited) – Prescribing Information (2017)– ; DailyMed setid 051392d3-8ec1-450c-8c38-791d4ef1a2db