Minor
Amoxicillin × Levothyroxine sodium
Penicillins with extended spectrum×Thyroid hormones
Mechanism
Amoxicillin taken concurrently may slightly impair intestinal levothyroxine absorption. With separated dosing, the effect is clinically negligible.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
Take levothyroxine in the morning on an empty stomach, 30–60 minutes before food and other medications. Take amoxicillin 4 hours later or at lunch. For short amoxicillin courses (5–10 days), no special TSH monitoring needed.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)– Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)– Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024