Minor
Amoxicillin × Estradiol
Penicillins with extended spectrum×Estrogens — natural and semisynthetic
Mechanism
Same as the ethinylestradiol pair: meta-analyses did not confirm clinically significant reductions in hormone therapy efficacy with broad-spectrum antibiotics.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
For short amoxicillin courses (5–10 days) in women on menopausal hormone therapy, no adjustment needed. Vasomotor symptom monitoring follows the usual schedule.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- KDIGO: KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of CKD (2024)– Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int 2024;105(4S):S117-S314.