Minor
Azithromycin × Estradiol
Macrolides×Estrogens — natural and semisynthetic
Mechanism
Azithromycin has minimal effect on CYP3A4 and does not affect hepatic oestradiol metabolism. No clinically significant reduction in menopausal hormone therapy efficacy has been reported.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. In women on menopausal hormone therapy, azithromycin remains an antibiotic of choice for respiratory infections.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.