ModeratePenicillins with extended spectrum×Vitamin K antagonist anticoagulants
Updated · Methodology
Mechanism
Amoxicillin may reduce gut flora vitamin K synthesis – INR mildly rises. Effect usually moderate.
Symptoms
INR above target, occasional bleeding.
Management
Check INR on day 5 if course longer than 5 days.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)– Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)– Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024
- DailyMed: Warfarin: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Amoxicilina (nº registro 62880), sección 4.5 (2023)– AEMPS, CIMA, nº registro 62880, revisión 05/2023, sección 4.5