MajorPolyene systemic antifungal×Aminoglycoside antibiotic
Updated · Methodology
Mechanism
Both nephrotoxic. Combined use gives additive AKI risk.
Symptoms
Creatinine rise within 5-7 days.
Management
Daily creatinine monitoring, minimise course duration.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Gentamicin sulfate injection prescribing information (2018)– FDA gentamicin label, boxed warning
- AEMPS: Ficha técnica: Gentamicina (nº registro 63854), sección 4.5 (2024)– AEMPS, CIMA, nº registro 63854, revisión 10/2024, sección 4.5