MajorPolyene systemic antifungal×Cardiac glycosides (digitalis)
Updated · Methodology
Mechanism
Amphotericin B causes hypokalaemia, which enhances digoxin binding to cardiomyocyte Na-K-ATPase and potentiates digoxin toxicity.
Symptoms
Bradycardia, arrhythmia, yellow vision.
Management
Check potassium and digoxin levels. Replacement therapy.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Fungizone (amphotericin B) prescribing information (2014)– FDA Fungizone label