Major
Digoxin × Ticagrelor
Cardiac glycosides (digitalis)×Reversible P2Y12 receptor inhibitor
Mechanism
Ticagrelor inhibits renal P-glycoprotein. Digoxin rises 1.3-fold.
Symptoms
Nausea, yellow vision, bradycardia.
Management
Check digoxin level 1 week after ticagrelor start.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.