CriticalMacrolide antibiotic×Reversible P2Y12 receptor inhibitor
Updated · Methodology
Mechanism
Clarithromycin is a strong CYP3A4 inhibitor. Ticagrelor rises 5-fold.
Symptoms
Bleeding.
Management
Combination contraindicated. Alternative – azithromycin (no CYP3A4 inhibition).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Brilinta (ticagrelor) prescribing information, Section 4.3 (2015)
- AEMPS: Ficha técnica: Claritromicina (nº registro 75638), sección 4.3 (2025)– AEMPS, CIMA, nº registro 75638, revisión 03/2025, sección 4.3
- AEMPS: Ficha técnica: Ticagrelor (nº registro 89536), sección 4.3 (2026)– AEMPS, CIMA, nº registro 89536, revisión 08/2026, sección 4.3