Critical
Clarithromycin × Ticagrelor
Macrolide antibiotic×Reversible P2Y12 receptor inhibitor
Mechanism
Clarithromycin is a strong CYP3A4 inhibitor. Ticagrelor rises 5-fold.
Symptoms
Bleeding.
Management
Combination contraindicated. Alternative – azithromycin (no CYP3A4 inhibition).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.