MajorPolyene systemic antifungal×Thiazide diuretics
Updated · Methodology
Mechanism
Both cause renal potassium loss. Dual hypokalaemia with arrhythmia risk.
Symptoms
K+ below 3.0 mmol/L, weakness, arrhythmia.
Management
Daily potassium check, potassium and magnesium replacement.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Fungizone (amphotericin B) prescribing information (2014)– FDA Fungizone label
- AEMPS: Ficha técnica: Hidroclorotiazida (nº registro 86487), sección 4.5 (2026)– AEMPS, CIMA, nº registro 86487, revisión 09/2026, sección 4.5