CriticalClass III antiarrhythmic, selective IKr blocker×Thiazide diuretics
Updated · Methodology
Mechanism
Hydrochlorothiazide causes hypokalaemia and hypomagnesaemia; combined with dofetilide leads to torsades de pointes. FDA Tikosyn Section 4.3 strict contraindication.
Symptoms
Torsades de pointes, syncope, cardiac arrest.
Management
Combination contraindicated. Use loop diuretic with potassium monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Tikosyn (dofetilide) prescribing information (2019)– FDA Tikosyn label, Section 4 Contraindications
- AEMPS: Ficha técnica: Hidroclorotiazida (nº registro 86487), sección 4.5 (2026)– AEMPS, CIMA, nº registro 86487, revisión 09/2026, sección 4.5