MajorHMG-CoA reductase inhibitors (statins)×Triazole derivatives, systemic antifungals
Updated · Methodology
Mechanism
Voriconazole inhibits CYP3A4. Atorvastatin rises 3-4 fold.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Cap atorvastatin at 20 mg/day.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lipitor (atorvastatin) prescribing information, Section 7 Drug Interactions (2017)
- AEMPS: Ficha técnica: Atorvastatina (nº registro 69536), sección 4.5 (2024)– AEMPS, CIMA, nº registro 69536, sección 4.5