MajorImmunosuppressants. Calcineurin inhibitors×Triazole derivatives, systemic antifungals
Updated · Methodology
Mechanism
Voriconazole inhibits CYP3A4. Cyclosporine rises 1.7-fold.
Symptoms
Nephrotoxicity.
Management
Halve cyclosporine dose.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Vfend (voriconazole) prescribing information – CYP3A4 inhibitor, statin/immunosuppressant interactions (2020)– FDA Vfend label, Drug Interactions §7 – tacrolimus, cyclosporine, sirolimus, statins; DailyMed setid ce3ef5cf-3087-4d92-9d94-9eb8287228db
- EMA: Vfend (voriconazole) Summary of Product Characteristics, Section 4.3 (2024)
- AEMPS: Ficha técnica: Voriconazol (nº registro 80105), sección 4.5 (2026)– AEMPS, CIMA, nº registro 80105, sección 4.5