CriticalProkinetic, 5-HT4 serotonin receptor agonist (withdrawn EU/US)×Antifungal, triazole
Updated · Methodology
Mechanism
Itraconazole is the strongest CYP3A4 inhibitor. Cisapride rises 10+ fold. Fatal torsades.
Symptoms
Torsades de pointes.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Propulsid (cisapride) prescribing information withdrawal (2000)– FDA withdrawal letter, 2000
- AEMPS: Ficha técnica: Itraconazol (nº registro 65775), sección 4.3 (2026)– AEMPS, CIMA, nº registro 65775, revisión 04/2026, sección 4.3