CriticalErgot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist×Antifungal, triazole
Updated · Methodology
Mechanism
Strongest CYP3A4 inhibitor – dihydroergotamine rises 20+ fold.
Symptoms
Fatal ergotism.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Migranal (dihydroergotamine) prescribing information (2020)– FDA Migranal label, Section 4
- AEMPS: Ficha técnica: Itraconazol (nº registro 65775), sección 4.3 (2026)– AEMPS, CIMA, nº registro 65775, revisión 04/2026, sección 4.3