Major
Ciclosporin × Itraconazole
Immunosuppressants. Calcineurin inhibitors×Antifungal, triazole
Mechanism
Strong CYP3A4 inhibitor. Cyclosporine rises 5+ fold.
Symptoms
Nephrotoxicity.
Management
Reduce cyclosporine by 75%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.