MajorImmunosuppressants. Calcineurin inhibitors×Antifungal, triazole
Updated · Methodology
Mechanism
Strong CYP3A4 inhibitor. Cyclosporine rises 5+ fold.
Symptoms
Nephrotoxicity.
Management
Reduce cyclosporine by 75%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Sandimmune (cyclosporine) prescribing information (2015)
- AEMPS: Ficha técnica: Ciclosporina (nº registro 78331), sección 4.5 (2026)– AEMPS, CIMA, nº registro 78331, revisión 06/2026, sección 4.5
- AEMPS: Ficha técnica: Itraconazol (nº registro 65775), sección 4.5 (2026)– AEMPS, CIMA, nº registro 65775, revisión 04/2026, sección 4.5