CriticalImmunosuppressants. Calcineurin inhibitors×Statin (HMG-CoA reductase inhibitor)
Updated · Methodology
Mechanism
Cyclosporine inhibits OATP1B1 – pitavastatin rises 5-7 fold. FDA Livalo contraindication.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Livalo (pitavastatin) prescribing information (2013)
- AEMPS: Ficha técnica: Pitavastatina (nº registro 84972), sección 4.3 (2026)– AEMPS, CIMA, nº registro 84972, revisión 03/2026, sección 4.3