CriticalImmunosuppressants. Calcineurin inhibitors×HMG-CoA reductase inhibitors (statins)
Updated · Methodology
Mechanism
Cyclosporine inhibits OATP1B1 – rosuvastatin hepatic uptake falls, plasma concentration rises 7-fold. FDA Crestor Section 7 contraindication.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Combination contraindicated. Alternative – pravastatin 20 mg (minimal risk).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Crestor (rosuvastatin) prescribing information (2017)
- AEMPS: Ficha técnica: Rosuvastatina (nº registro 82270), sección 4.3 (2026)– AEMPS, CIMA, nº registro 82270, revisión 03/2026, sección 4.3