Major
Ciclosporin × Posaconazole
Immunosuppressants. Calcineurin inhibitors×Second-generation systemic triazole antifungal
Mechanism
Strong CYP3A4 inhibitor. Cyclosporine rises 1.4-fold.
Symptoms
Nephrotoxicity.
Management
Reduce cyclosporine by 25%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Noxafil (posaconazole) Summary of Product Characteristics (2024)– EMA EPAR Noxafil