CriticalErgot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist×Second-generation systemic triazole antifungal
Updated · Methodology
Mechanism
Posaconazole is a strong CYP3A4 inhibitor. EMA Noxafil Section 4.3 strict contraindication.
Symptoms
Fatal ergotism.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Noxafil (posaconazole) Summary of Product Characteristics (2024)– EMA EPAR Noxafil
- AEMPS: Ficha técnica: Posaconazol (nº registro 90284), sección 4.5 (2025)– AEMPS, CIMA, nº registro 90284, revisión 04/2025, sección 4.5