CriticalSecond-generation systemic triazole antifungal×Vinca alkaloid, microtubule assembly inhibitor
Updated · Methodology
Mechanism
Same CYP3A4 + P-gp pharmacodynamics. Fatal neurotoxicity.
Symptoms
Severe neuropathy.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Oncovin (vincristine) prescribing information (2013)– FDA Oncovin label, Section 4.3
- AEMPS: Ficha técnica: Posaconazol (nº registro 90284), sección 4.5 (2025)– AEMPS, CIMA, nº registro 90284, revisión 04/2025, sección 4.5