CriticalAntifungal, triazole×Vinca alkaloid, microtubule assembly inhibitor
Updated · Methodology
Mechanism
Itraconazole inhibits CYP3A4 and P-gp. Vincristine rises 5+ fold – fatal neurotoxicity with motor deficit and autonomic neuropathy.
Symptoms
Severe peripheral neuropathy, paralytic ileus, autonomic disorders.
Management
Combination contraindicated. Alternative antifungal – micafungin or caspofungin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Oncovin (vincristine) prescribing information (2013)– FDA Oncovin label, Section 4.3