CriticalLong-acting dopamine D2 receptor agonist, ergot derivative×Antifungal, triazole
Updated · Methodology
Mechanism
Itraconazole is the strongest CYP3A4 inhibitor. Cabergoline rises 5-7 fold. Valvulopathy and pulmonary fibrosis risk.
Symptoms
Dyspnoea, cardiac murmurs, edema.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha tecnica de Dostinex (cabergolina) (2023)– AEMPS CIMA, 2023