CriticalErgot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist×Triazole derivatives, systemic antifungals
Updated · Methodology
Mechanism
Voriconazole is a strong CYP3A4 inhibitor. Ergotamine rises 10+ fold. EMA Vfend Section 4.3.
Symptoms
Fatal ergotism.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Vfend (voriconazole) Summary of Product Characteristics, Section 4.3 (2024)
- AEMPS: Ficha técnica: Voriconazol (nº registro 80105), sección 4.3 (2026)– AEMPS, CIMA, nº registro 80105, revisión 04/2026, sección 4.3