CriticalPharmacokinetic enhancer (booster) for antiretroviral therapy×Ergot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist
Updated · Methodology
Mechanism
Cobicistat is a strong CYP3A4 inhibitor. EMA Tybost Section 4.3 strict contraindication with ergot alkaloids.
Symptoms
Fatal ergotism.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Tybost (cobicistat) Summary of Product Characteristics (2024)– EMA EPAR Tybost