CriticalSecond-generation HIV protease inhibitor×Ergot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist
Updated · Methodology
Mechanism
CYP3A4 inhibition – fatal ergotism.
Symptoms
Limb ischaemia, stroke.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Prezista (darunavir) SmPC (2024)– EMA EPAR Prezista
- AEMPS: Ficha técnica: Darunavir (nº registro 83164), sección 4.3 (2024)– AEMPS, CIMA, nº registro 83164, revisión 02/2024, sección 4.3