CriticalErgot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist×Systemic antimycotics. Imidazole derivatives
Updated · Methodology
Mechanism
Ketoconazole is a strong CYP3A4 inhibitor. Ergotamine rises 15-fold, fatal ergotism.
Symptoms
Limb ischaemia within 24 hours.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Ergomar (ergotamine) prescribing information, Section 4 (2008)– ; DailyMed setid a9582fdb-7ddd-4f69-aa7a-66247cdb8c92