Major
Fluoxetine × Ibuprofen
Selective serotonin reuptake inhibitors×Non-steroidal anti-inflammatory drugs (NSAIDs)
Mechanism
SSRI + NSAID – increased GI bleeding risk.
Symptoms
GI bleeding in at-risk patients.
Management
PPI gastroprotection or paracetamol alternative.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.