MajorSelective serotonin reuptake inhibitors×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
SSRI + NSAID – increased GI bleeding risk.
Symptoms
GI bleeding in at-risk patients.
Management
PPI gastroprotection or paracetamol alternative.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- DailyMed: Fluoxetine: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Fluoxetina (nº registro 63499), sección 4.5 (2026)– AEMPS, CIMA, nº registro 63499, revisión 10/2026, sección 4.5
- AEMPS: Ficha técnica: Ibuprofeno (nº registro 63597), sección 4.4 (2025)– AEMPS, CIMA, nº registro 63597, revisión 04/2025, sección 4.4