CriticalOxazolidinone antibiotic×Antidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B)
Updated · Methodology
Mechanism
Linezolid is a reversible MAO inhibitor. Combined with phenelzine causes cumulative MAO inhibition and fatal serotonin syndrome with tyramine load.
Symptoms
Hypertensive crisis, hyperthermia, myoclonus.
Management
Combination contraindicated. Alternative antibiotic: vancomycin or daptomycin for MRSA.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Nardil (phenelzine sulfate) prescribing information (2009)– FDA Nardil label, Section 4 Contraindications; DailyMed setid 513a41d0-37d4-4355-8a6d-a2c643bce6fa
- AEMPS: Ficha técnica: Linezolid (nº registro 81569), sección 4.3 (2026)– AEMPS, CIMA, nº registro 81569, revisión 05/2026, sección 4.3