MinorBiguanides. Oral antihyperglycemic agents×Proton pump inhibitors
Updated · Methodology
Mechanism
Omeprazole weakly inhibits intestinal OCT1, the transporter mediating metformin absorption. Metformin bioavailability may rise slightly. Clinical significance is minimal.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. On long-term PPI therapy (over 2 years), check B12 yearly — both drugs may reduce its absorption.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- Lexicomp: Lexicomp Drug Interactions (2024)– Wolters Kluwer Clinical Drug Information, Inc. Lexi-Interact Online, 2024
- Pharmaceutical Press: Stockley's Drug Interactions, 12th edition (2024)– Preston CL (ed.). Stockley's Drug Interactions. 12th ed. London: Pharmaceutical Press; 2024