Ascorbyl Glucoside
Stable glycoside of ascorbic acid. Converted to vitamin C by alpha-glucosidase after skin penetration.
Evidence by route
Topical application
Stable vit C form, but requires β-glucosidase to convert to active ascorbic acid. Skin has minimal enzyme – conversion is poor. Popular in Japan, but limited clinical data on actual effect.
- Takada M, Yamada Y, Toriyama-Baba H, et al. Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos. Int J Mol Sci. 2024;25(24):13453.. PMID 39769217
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Working concentrations
- 2–10%
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Sensitive, Dry, Normal, Combination
Combinations with other ingredients
About this ingredient
Ascorbyl Glucoside (AA-2G) is a stable water-soluble form of vitamin C, an L-ascorbic acid conjugate with glucose. In the skin alpha-glucosidase gradually cleaves glucose to release active L-ascorbate. Where applied. Anti-aging serums and creams (1-5%), brightening products for hyperpigmentation, melasma, post-acne pigmentation. Often combined with niacinamide, ferulic acid, tocopherol. Popular in La Roche-Posay Pure Vitamin C, Vichy LiftActiv, Sesderma C-Vit. Advantages over L-ascorbic acid. Stable in aqueous environment at pH 5-7 (unlike L-ascorbate, which oxidizes within days). Non-irritating even in sensitive skin and rosacea. Causes no redness. However, the active effect is weaker – requires enzymatic activation in the epidermis, and effective L-ascorbate concentration in skin is lower. Evidence base. Studies (Yamamoto 2006, Hwang 2009) showed brightening and antioxidant effects of 2-5% ascorbyl glucoside over 8-12 weeks of use. Effect comparable to 10-15% L-ascorbic acid but without irritation. A safe alternative in couperose and rosacea. Safety. CIR confirmed safety. Hypoallergenic. Irritation is rare. Non-comedogenic. Systemic absorption is minimal. Pregnancy and lactation – safe. Acceptable at any stage. Unlike L-ascorbic acid, does not photosensitize – can be used in the morning without mandatory SPF. Alternatives. Ethyl ascorbic acid (3-O-Ethyl Ascorbic Acid) – stable lipid-soluble form with better bioavailability. Tetrahexyldecyl ascorbate – lipid-soluble, for dry skin. Magnesium ascorbyl phosphate – stable, particularly at pH 7.
Frequently asked questions
Is Ascorbyl Glucoside safe during pregnancy?
Ascorbyl Glucoside is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Ascorbyl Glucoside for?
Ascorbyl Glucoside suits: sensitive, dry, normal, combination.
What is Ascorbyl Glucoside and what does it do in cosmetics?
Stable glycoside of ascorbic acid.
What's the INCI name for Ascorbyl Glucoside?
The INCI name is Ascorbyl Glucoside. It may also appear as: AA2G.
What concentration of Ascorbyl Glucoside is effective?
2–10%
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