Hyaluronic Acid (Low Molecular Weight)
INCI: Hydrolyzed Sodium Hyaluronate
Fragmented hyaluronic acid with a mass <50 kDa. Penetrates the epidermis better than the high-molecular form, but at high concentrations may trigger a pro-inflammatory response.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Studies show improved hydration and firmness with prolonged use. Epidermal penetration is confirmed, but some low-MW fragments activate TLR receptors, causing mild inflammation. The 'deep hydration vs. inflammation' balance depends on concentration and fragment size.
- Essendoubi M et al. PLoS One. 2016;11(2):e0146786.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Use with caution
Frequently asked questions
Is Hyaluronic Acid (Low Molecular Weight) safe during pregnancy?
Hyaluronic Acid (Low Molecular Weight) is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hyaluronic Acid (Low Molecular Weight) for?
Hyaluronic Acid (Low Molecular Weight) suits: dry, normal, combination. Use with caution in: sensitive.